Ghrelin protects against ethanolinduced gastric ulcers in. Alphalipoic acid improves acetic acidinduced gastric. They were kept in specially constructed cages to prevent coprophagia during and after the experiment. This study is aimed to evaluate the effect of zingerone on ethanolinduced gastric ulcers in rats. Pdf protective role of phoenix dactylifera fruit against. The present study was designed to investigate the cytoprotective and antiinflammatory properties of tertbutylhydroquinone tbhq, a nuclear factor erythroid 2related factor 2 nrf2 activator, against gastric mucosal damage induced by acute exposure of ethanol. The potentiating actions of cigarette smoking on ethanol. Research article ethanolinduced gastric ulcer in male wistar.
Antiulcerogenic effect of cuphea ignea extract against. Mechanisms of gastroprotective effects of ethanolic leaf extract of. Pdf antiulcerogenic effect of cuphea ignea extract. Influence of gender difference and gastritis on gastric. The rats were fasted for 24 h, the separate groups. Jasminum sambac is used in folk medicine as the treatment of many diseases. As shown in figure 1, the ethanol 96% administration induced extensive long and hemorrhagic gastric ulcers in the rat.
Pdf amelioration of ethanolinduced gastric ulcers in rats. Ethanolinduced gastric ulceration in rats semantic scholar. Balakrishnan1 school of biomedicine 1, asia metropolitan university, g8, jalan kemacahaya 11, batu 9, 43200 cheras, selangor, malaysia. Therapeutic effect of momordica balsamina leaf extract on.
Pdf gastroprotective effect of zingerone on ethanol. Gastroprotective activity of aqueous carica papaya seed. Research article ethanolinduced gastric ulcer in male. Antiulcerogenic effect of camel milk against ethanol. By 5 min, hyperemia greatly intensified at some mucosal sites. Ethanol induced ulcer model 22 the ulcer was induced by administering ethanol.
Substances other also been shown to induce microcirculatory abnormalithan nicotine could contribute to these adverse reac ties. Oral administration of camel milk in rats with ethanolinduced gastric ulcer. Biochanin a gastroprotective effects in ethanolinduced. Effect of cardiospermum halicacabum on ethanolinduced. Studies on the mechanism of ethanolinduced gastric damage in rats. The gastro protective effects of cibotium barometz hair on. Conventional histology and immunohistochemistry for ghrelin, gastrin, and somatostatin were performed on gastric specimens from representative rats. Mda contents were evaluated in ethanolinduced ulcer in vivo. Thus, the current study aimed to investigate the potential protective effects of dio against ethanolinduced gastric injury in rats. Research article gastroprotective effects of lion s mane mushroom hericium erinaceus bullfr. Indomethacin and ethanol induced ulcer models the common parameter determined was ulcer index. Several studies have investigated the effect of zingerone on various gastrointestinal diseases, including irritable bowel syndrome and diarrhea.
In the present study we investigated the gastroprotective effect of citrus sinensis peel aqueous extract cspe and hesperidin h in ethanol etoh induced oxidative stress and peptic ulcer in rats. Within 1 min of contact, ethanol caused diffuse mucosal hyperemia. Antiulcer activity of swietenia mahagoni leaf extract in ethanolinduced gastric mucosal damage in rats. Acute gastritis or gastric ulcer was induced in the rat stomach by 80% ethanol or 60% acetic acid, respectively. Ethanol induced gu in animal model resembles the pathophysiology of human ulcer. Amelioration of ethanolinduced gastric ulcers in rats pretreated. Roles of nitric oxide in protective effect of berberine in. Sapindaceae, in a concentration dependant manner 200600 mgkg inhibited gastric ulcers induced by oral administration of absolute ethanol. Gastric ulcers were induced by ethanol 96%, 5 mlkg, po in male wistar rats and zingerone 50, 100, and 200 mgkg was administrated orally. Rjpt gastro protective effect of standardized ethanolic.
Groups six and seven had animals treated with folic acid 2 mgkg and 3 mgkg for twentyone days and omeprazole for the penultimate seven days respectively. Pdf antiulcer activity of swietenia mahagoni leaf extract. Original article aripiprazole an atypical antipsychotic. Ulcer can be induced by administration of hpylori, nonsteroidal antiinflammatory drugs and by environmental and life style factors prabhu and shivani 2014. In this study, the preventive effects of the crude extract of scutia buxifolia cesb against gastric ulcer induced by 70% ethanol were evaluated in male wistar rats. Evaluation of the antiulcer effect of aerva javanica. To investigate the protective effects of berberine on ethanolinduced gastric ulcer in mice. According to yonei and guth 1 the gastric submucosal microvascular disturbance resulting in local ische. Exposure of rats to ethanol resulted in gastric mucosal injury and a high index of ulcer. Folic acid supplementation ameliorates inflammation and. Forty adult wistar rats of either sex were marked, weighed and randomly assorted into 5 groups ae with each group containing 8 rats. Alphalipoic acid improves acetic acidinduced gastric ulcer. Gastric ulcer, protective effect, ethanol falcaria vulgaris locally named ghazzyaghi poghazeh is a member of umbelliferae family which grows near farmlands and is consumed as a vegetable in some regions of iran.
Meanwhile, overall control rats group one received distilled water, while ulcer control group group two received ethanol only. Diazoxide, a katp channel opener, prevented ethanol. Ganoderma lucidum pharmacopuncture for teating ethanol. Relationship between ethanolinduced gastritis and gastric ulcer.
Ethanol causes necrotic lesions that reduce gastrointestinal tract defensive factors like bicarbonate secretion and the production of mucus and its circulation 2224. Oral pretreatment with zingerone attenuated the number and the length of gastric lesions in a dosedepended manner p ethanolinduced gastric lesions as shown in figure 1, the ethanol 96% administration induced extensive long and hemorrhagic gastric ulcers in the rat. The preliminary phytochemical evaluation was carried out by standard methods. The effect of nicotine on ethanolinduced gastric ulcers. The anti ulcer activity of ethanolic extract of indigofera tinctoria fabaceae leaf eeit was investigated in indomethacin and ethanol induced ulcer models in wistar rats. Pdf amelioration of ethanolinduced gastric ulcers in.
Methanol leaf extract of actinodaphne sesquipedalis lauraceae enhances gastric defense against ethanolinduced ulcer in rats hanita omar,1,2 noraziah nordin,3 pouya hassandarvish,4 maryam hajrezaie,5 ainnul hamidah syahadah azizan,1 mehran fadaeinasab,6 nazia abdul majid,7 mahmood ameen abdulla,5 najihah mohd hashim,3 hapipah mohd ali1 1department of chemistry, faculty of. Therapeutic effect of momordica balsamina leaf extract on ethanolinduced gastric ulcer in wistar rats background. Rats were killed either with gastritis alone or thereafter at day 1, 3 or 6 after ulcer induction. Antiulcerogenic effect of camel milk against ethanol induced. Moreover, the alcoholinduced decrease in stomach antioxidant enzyme activity found in the ulcer control group was prevented by exphy. Gastroprotective effect of zingerone on ethanolinduced gastric ulcers in rats article pdf available in medicina kaunas, lithuania 553. Phycobiliproteins of arthrospira spirulina maxima have attracted attention because of their potential therapeutic antioxidant properties. Ulceration was induced by oral administration of absolute ethanol 1cm3kg body weight. Gastric ulcer index, microscopic score, elevated dna fragmentation and chemiluminescence. Suppressive effect of melatonin administration on ethanol. Mar 11, 2019 this study is aimed to evaluate the effect of zingerone on ethanolinduced gastric ulcers in rats. One hour after ethanol administration blood samples were. Research article gastroprotective effects of lion s mane. For acute toxicity test 300 mg kg 1 2pentadecanone was orally given to rats, followed by 2 weeks observation period to confirm the.
The aim of this study was to assess the possible antiulcerogenic activity of these phycobiliproteins exphy against ethanolinduced gastric ulcers in rats. Gastroprotective activity of ethyl43,5ditertbutyl2. Taken together, the findings of this research amply demonstrated that weac exerted appreciable gastroprotective effect against ethanolinduced gastric ulcer in rats. Results showed that rats pretreated with omeprazole or j. This study aimed to evaluate acute toxicity and ulcer inhibitory effect of 2pentadecanone as a ketone bioactive compound against ethanolinduced gastric ulcer in sprague dawley rats.
The number of proliferating and apoptotic cells, the mucosal mucus and prostaglandin e 2 pge 2 level were also determined. Antiulcerogenic activity of scutia buxifolia on gastric. Gastroprotective effect of zingerone on ethanolinduced gastric. In this study, we determine the cytotoxic, antioxidant and gastroprotective effect of ethab against ethanolinduced gastric mucosal ulcer in rats. Groups six and seven had animals treated with folic acid 2 mgkg and 3 mgkg for twentyone days and omeprazole for. Evaluation of preventive effect of withania somnifera root extract against ethanol induced ulcers in rats. We have investigated this mechanism in the rat stomach via gross morphologic, videomicroscopic, histochemical, and pharmacologic approaches. Ethanolinduced rodent gastric ulcer model creative biolabs. The effect of oral administration of raw camel milk 5 mlkg b. The effect of nicotine on ethanolinduced gastric ulcers in rats. Pdf gastroprotective effect of zingerone on ethanolinduced. Antiulcerogenic activity of scutia buxifolia on gastric ulcers induced. Ethanolinduced gu in animal model resembles the pathophysiology of human ulcer. Protective effect of falcaria vulgaris extract on ethanol.
To evaluate the role of ala treatment on the healing of acetic acidinduced gastric ulcer, rats were given ala 35 mgkgday or saline for 3 days before the induction of ulcer and the treatment was continued twice daily for 2 days early or 10 days late until they were decapitated. Antioxidant effects of some drugs on ethanol induced ulcers author. Concentrated ethanol causes gastric lesions by a mechanism that is poorly understood. The gastric ulcers were induced in rats of either sex weighing between 150 g by administrating absolute ethanol 8 mlkg. Gastric ulcer index, microscopic score, elevated dna fragmentation and chemiluminescence levels of the saline. The results of the current research revealed that following fed the rats with biochanin a the protein concentration preserved in the homogenate stomach tissue. The aim of this work was to investigate the antioxidant potential of some commonly used drugs bromocriptine, haloperidol and azithromycin on alcohol induced ulcers in the rat. For each extract, adult wistar rats of either sex were marked, weighed and randomly assorted into eight groups with each group containing five rats. Antiulcer and antioxidant activity of moringa oleifera. Amelioration of ethanolinduced gastric ulcers in rats. All the animals were fasted for 36 hours before administration of ethanol.
Gastric emptying rate was calculated through the formula. Introduction of peptic ulcer peptic ulcer is among the most predominant gastrointestinal diseases in the world and is characterized by ulceration in the stomach and duodenum. Gastric ulcer was induced in overnight fasted rats that. Gastric ulcers were induced by oral ingestion of ethanol. Mechanisms of gastroprotective effects of ethanolic leaf. Antioxidative and antiinflammatory effects of water extract.
Evaluation of gastroprotective activity of myristica. This agent is also effective as mucosal protection in treatment of nonacid depended models such as ethanol induced ulcer model 3, 7, 30. Materials and methods experimental animals adult male rats weighing between 150 g and 200 g bred in the pre clinical animal house of the college of medicine and health sciences, afe babalola university, ado. Results antiulcer study gross estimations the results that pretreated with c. Gastric ulcers were induced in sprague dawley rats using one oral dose of absolute ethanol 1. Pdf gastroprotective effects of pistacia atlantica extract on. Evaluation of antiulcer activity of methanolic extract of. The aim of the present investigation is to evaluate the gastroprotective effects of ethanolic extracts of j. Antiulcer and antioxidant activity of moringa oleifera lam. Seven groups of rats were orally pretreated with carboxymethylcellulose cmc as normal group, cmc as ulcer group, 20 mgkg of omeprazole. Ethanolinduced gastric ulcer in rats and intervention of. To explore the possible mechanisms of action, we examined antioxidant defense enzymes e. Methanol leaf extract of actinodaphne sesquipedalis.
Histological analyses and studies of antioxidant and antiinflammatory activities were. A doseeffect relation was constructed using the ethanolinduced gastric ulcer model in male wistar rats. Acute exposure of the gastric mucosa of rats to ethanol can result in gastric lesions similar to those occurring in gastric ulcer. Gastroprotective effect of zingerone on ethanolinduced. Aphyllophoromycetideae extract against ethanolinduced ulcer in rats jingyangwong, 1,2 mahmoodameenabdulla, 1,3 jegadeeshraman, 1 chiaweiphan, 1,2 umahranikuppusamy, 1,3 shahramgolbabapour, 2,3 andvikineswarysabaratnam 1,3. Further, the extract administration to rats resulted in an increase in levels of gastric glutathione and a decrease in alkaline phosphatase activity. Evaluation of preventive effect of withania somnifera root. Studies on the mechanism of ethanolinduced gastric damage. Daniel hollander and his colleagues induced ulcer with ethanol in rats to evaluate the gastroprotective. Pdf gastroprotective effects of betanin against ethanol. At creative biolabs, we offer ethanolinduced gastric ulcer models induced in both rats and mice. Administration with weac not only markedly increased the activities of cat, sod, and gsh, decreased the level of mda, but also reduced the productions of tnf. Antioxidative and antiinflammatory effects of water. Central ghrelin 44000 ngrat dosedependently reduced ethanolinduced gastric ulcers by 3977%.
Diazoxide, a katp channel opener, prevented ethanolinduced. In acute toxicity study, a high dose of gkg did not manifest any toxicological signs in rats. Protective effect of falcaria vulgaris extract on ethanol induced gastric ulcer in rat ijpt. Antioxidant effects of some drugs on ethanolinduced ulcers. October 1997 smokingethanol and gastric mucosal damage 1189 potentiate both ethanol and stressinduced gastric muexperiment. Seven groups of rats were orally pretreated with carboxymethylcellulose cmc as normal. See desquamated mucosal cells red arrows from the surface of epithelium and. Therapeutic effect of low molecular weight chitosan. Cyathula prostrata on ethanol induced gastric ulcer in rats ethanol induced ulcer in rats were valuated as described by ode and asuzu 2011 15. Santha maria1, surya devarakonda 1, ajay kumar tv 2 and n. Normal saline and ranitidine were used as negative and positive control. Materials and methods experimental animals adult male rats weighing between 150 g and 200 g bred in the pre clinical animal house of the college of medicine and health sciences, afe babalola university, adoekiti were used.